沈阳药科大学学报

2025, v.42;No.356(09) 812-819

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北枳椇树干中的化学成分研究
Constituents from the stems of Hovenia dulcis Thunb.

徐方方,吴烦,杨建展,蔡婉娜,张晓琦,刘博
XU Fangfang,WU Fan,YANG Jianzhan,CAI Wanna,ZHANG Xiaoqi,LIU Bo

摘要(Abstract):

目的 对北枳椇(Hovenia dulcis Thunb.)树干的化学成分开展研究。方法 采用硅胶、ODS、Sephdex LH-20等色谱技术对北枳椇树干中的化学成分进行分析分离,利用NMR、LC/MS、IR、UV和旋光波谱仪等技术并结合文献对单体化合物的结构进行确证,利用CCK-8法测定化合物的抗肿瘤活性。结果 从北枳椇树干体积分数70%乙醇提取物中得到15个成分,分别鉴定为羽扇豆醇(1)、白桦脂酸(2)、麦珠子酸(3)、3β-O-trans-p-coumaroyl alphitolic acid(4)、β-谷甾醇(5)、柚皮素(6)、根皮素(7)、5,7-dihydroxy-2-[2-(4-hydroxyphenyl) ethyl]chromone(8)、(+)-阿夫儿茶精(9)、(-)-表阿夫儿茶精(10)、儿茶素(11)、墨沙酮(12)、4-羟基苯戊酸(13)、(-)-杜仲树脂酚(14)、7,10-二羟基硬脂酸(15)。结论化合物1、8、14和15为首次从枳椇属中分离得到,化合物13为首次得到的天然产物,化合物4表现出一定的抗肿瘤作用。
Objective The chemical compounds from the stems of Hovenia dulcis Thunb. were studied. Methods The compounds were purified by many separation methods including silica gel,ODS,and Sephadex LH-20. The structures were elucidated by spectral data including NMR,LC/MS,IR,UV and ORD,combined with literature references. The CCK-8 method was used to evaluated the anticancer activities of the isolated constituents. Results Fifteen compounds were identified as lupeol (1),betulinic acid (2),alphitolic acid (3),3β-O-trans-p-coumaroyl alphitolic acid (4),β-sitosterol (5),naringenin (6),phloretin (7),5,7-dihydroxy-2-[2-(4-hydroxyphenyl) ethyl]chromone (8), (+)-afzelechin (9),(-)-epiafzelechin (10),catechin (11),maesopsin (12),4-hydroxybenzenepentanoic acid (13),(-)-medioresinol (14),7,10-dihydroxyoctadecanoic acid (15). Conclusion Compounds 1,8,14 and 15 are firstly isolated from genus Hovenia and compound 13 is firstly obtained as a natural product. Compound 4 shows the anti-tumor effects.

关键词(KeyWords): 北枳椇;化学成分;萜类;黄酮;抗肿瘤作用
Hovenia dulcis Thunb.;chemical constituent;triterpenoid;flavonoid;anti-tumor effect

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金项目(82173700,82474216);; 广东省科技计划项目(2023B1212060062,2023B1212060063);; 广州市科技局项目(2024A04J9997,2025A03J4085,2023A03J0240)

作者(Author): 徐方方,吴烦,杨建展,蔡婉娜,张晓琦,刘博
XU Fangfang,WU Fan,YANG Jianzhan,CAI Wanna,ZHANG Xiaoqi,LIU Bo

DOI: 10.14066/j.cnki.cn21-1349/r.2024.0657

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