| 1,366 | 138 | 6 |
| 下载次数 | 被引频次 | 阅读次数 |
目的研究桑白皮总黄酮镇咳祛痰作用。方法采用浓氨水、SO2小鼠引咳法,小鼠气管酚红排泌及大鼠气管毛细管分泌液模型,观察桑白皮黄酮的镇咳祛痰作用。结果125 mg.kg-1显著抑制浓氨水、SO2所致小鼠咳嗽潜伏期,减少氨水引咳次数,桑白皮总黄酮250 mg.kg-1显著减少SO2引咳次数。桑白皮总黄酮125 mg.kg-1增加小鼠气管酚红排泌,桑白皮总黄酮180 mg.kg-1显著增加大鼠气管分泌液。结论桑白皮总黄酮具有镇咳祛痰作用。
Abstract：Objective To study the antitussive and expectorant effects of the flavonoid of Cortex Mori(FCM).Methods The cough models were induced by ammonia and SO2 in mice,respectively.The excretory amount of sputum was determined by phenolsulfonphthalein excretion method in mice and the liquid excretion quantity of the airway in rats,respectively.Results The latency of cough induced by ammonia and SO2 in mice was significantly prolonged by FCM 125 mg·kg-1 and the number of cough was significantly diminished by FCM 125 mg·kg-1in ammonia induced mice model and FCM 250 mg·kg-1 in SO2 induced mice model,respectively.The phenolsulfonphthalein excretion quantity of tracheal in mice and the liquid secretion from the airway in rats were increased by FCM 125 mg·kg-1 and 180 mg·kg-1,respectively.Conclusion FCM has antitussive and expectorant effect.
[1]SOHN HY,SON K H,KWON C S,et al.Antimicrobialand cytotoxic activity of 18 prenylated flavonoids isola-ted from medicinal plants:Morus alba L.,Morus mon-golicaSchneider,Broussnetia papyrifera(L.)Vent,So-phora flavescensAit andEchinosophora koreensisNakai[J].Phytomedicine,2004,11(7-8):666-672.
[2]冯冰虹,赵宇红,黄建华.桑白皮的有效成分筛选及其药理学研究[J].中药材,2004,27(3):204-205.
[3]李松,闵阳,刘泉海.桑白皮醇提取物对白三烯拮抗活性的研究(1)[J].沈阳药科大学学报,2004,21(2):130-132,137-140.
[4]李松,闵阳,刘泉海.桑白皮醇提取物对白三烯拮抗活性的研究(2)[J].沈阳药科大学学报,2004,21(2):137-140.
[5]罗士德,NEMEC J,宁冰梅.桑白皮中抗人HIV成分研究[J].云南植物研究,1995,17(1):89-95.
[6]YOSHIO H,SHINKICCHI S.Two new phenolic com-pounds,kuwanols C and D,from the root bark of a mul-berry tree[J].Heterocycles,1989,29(4):807-813.
[7]OHH,KO E K,JUN Jung-yang,et al.Hepatoprotectiveand free radical scavenging activities of prenylfla-vonoids,coumarin,and stilbene fromMorus alba[J].Planta Medica,2002,68(10):932-934.
[8]冯冰虹,苏浩冲,杨俊杰.桑白皮丙酮提取物对呼吸系统的药理作用[J].广东药学院学报,2005,21(1):47-49.
[9]阚启明,康宁,田海涛,等.桑皮苷的镇咳平喘作用[J].沈阳药科大学学报,2006,23(6):388-391.
[10]张国刚,黎琼红,李乐道,等.桑白皮中总黄酮提取工艺研究[J].中草药,2005,36(11):1662.
[11]徐世义,张国刚,张洪霞,等.桑白皮药材质量控制研究[J].中药材,2006,29(2):184-186.
基本信息:
DOI：10.14066/j.cnki.cn21-1349/r.2009.08.010
中图分类号:R285.5
引用信息:
[1]韦媛媛,徐峰,陈侠,等.桑白皮总黄酮的镇咳祛痰作用[J].沈阳药科大学学报,2009,26(08):644-647.DOI:10.14066/j.cnki.cn21-1349/r.2009.08.010 .
2009-08-20
2009-08-20